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Proceedings Paper

Labeling of subcellular redox potential with dopamine-conjugated quantum dots
Author(s): Stephen E. Bradforth; Samuel J. Clarke; C. Annette Hollmann; Daniel Bahcheli; Jay L. Nadeau
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Paper Abstract

Semiconductor quantum dots (QDs) possess highly reactive electrons and holes after photoexcitation. The energy of these electrons and holes can be deliberately modulated by attaching the QD to an electron donor or acceptor. This eliminates (quenches) QD fluorescence, as well as affecting the ability of the QD to oxidize or reduce common biomolecules such as glutathione and DNA. This greatly alters the fluorescent properties and toxicity of such QDs inside cells. In this work, we show that a specific electron donor, the neurotransmitter dopamine, yields redox-sensitive conjugates when attached to at least some colors of CdSe/ZnS QDs. The potential for the use of such conjugates as sensors, and the implications for enhanced toxicity in such conjugates are discussed.

Paper Details

Date Published: 27 March 2006
PDF: 12 pages
Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 60960O (27 March 2006); doi: 10.1117/12.663332
Show Author Affiliations
Stephen E. Bradforth, Univ. of Southern California (United States)
Samuel J. Clarke, McGill Univ. (Canada)
C. Annette Hollmann, McGill Univ. (Canada)
Daniel Bahcheli, McGill Univ. (Canada)
Jay L. Nadeau, Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 6096:
Colloidal Quantum Dots for Biomedical Applications
Marek Osinski; Kenji Yamamoto; Thomas M. Jovin M.D., Editor(s)

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