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Proceedings Paper

Cytotoxical products formation on the nanoparticles heated by the pulsed laser radiation
Author(s): Boris Ya. Kogan; Andrey A. Titov; Victor Yu. Rakitin; Larisa D. Kvacheva; Sergey G. Kuzmin; Georgy N. Vorozhtsov
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Paper Abstract

Cytotoxical effect of a pulsed laser irradiation in presence of nanoparticles of carbon black, sulphuretted carbon and fullerene-60 on death of human uterus nick cancer HeLa and mice lymphoma P 388 cells was studied in vitro. Bubbles formation as result of "microexplosions" of nanoparticles is one of possible mechanisms of this effect. Other possible mechanism is cytotoxical products formation in result of pyrolysis of nanoparticles and biomaterial which is adjoining. The cytotoxical effect of addition of a supernatant from the carbon nanoparticles suspensions irradiated by the pulsed laser was studied to test this assumption. Analysis using gas chromatograph determined that carbon monoxide is principal gaseous product of such laser pyrolysis. This is known as cytotoxical product. Efficiency of its formation is estimated.

Paper Details

Date Published: 28 February 2006
PDF: 5 pages
Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 60950S (28 February 2006); doi: 10.1117/12.658131
Show Author Affiliations
Boris Ya. Kogan, Organic Intermediates and Dyes Institute (Russia)
Andrey A. Titov, ICP RAS 4 (Russia)
Victor Yu. Rakitin, Institute of Plant Physiology (Russia)
Larisa D. Kvacheva, A.N. Nesmeyanov Institute of Organoelement Compounds (Russia)
Sergey G. Kuzmin, Organic Intermediates and Dyes Institute (Russia)
Georgy N. Vorozhtsov, Organic Intermediates and Dyes Institute (Russia)

Published in SPIE Proceedings Vol. 6095:
Nanobiophotonics and Biomedical Applications III
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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