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Proceedings Paper

Induction of anti-tumor immunity by photodynamic therapy (PDT)
Author(s): Sandra O. Gollnick; Barbara Owczarczak; Patricia Maier
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Paper Abstract

Tumor directed PDT has been shown by a number of pre-clinical studies to enhance a specific anti-tumor immune response, which appears to be critical to long-term tumor growth control by PDT. The PDT enhanced immune response is T cell dependent, however the mechanism behind the potentiation of the immune response by PDT is unknown. Induction of T cell dependent immunity depends upon the presence of activated antigen presenting cells. Therefore we have examined the ability of PDT to stimulate maturation and activation of antigen presenting cells in the PDT-treated tumor bed and tumor draining lymph node. Our studies demonstrate and increase in the number of activated antigen presenting cells in the tumor bed 24h following treatment of EMT6 murine tumors with Photofrin-PDT. Tumor draining lymph nodes also showed increased levels of activated antigen presenting cells within 4h of treatment. The levels peaked at 24h and declined by 48h after PDT. These results demonstrate that PDT-enhanced anti-tumor immunity is accompanied by an increase in antigen presenting cell activity. Therefore it is possible that T cell dependent immunity is enhanced following PDT through enhanced antigen presenting cell activity.

Paper Details

Date Published: 23 February 2006
PDF: 6 pages
Proc. SPIE 6087, Biophotonics and Immune Responses, 60870E (23 February 2006); doi: 10.1117/12.649852
Show Author Affiliations
Sandra O. Gollnick, Roswell Park Cancer Institute (United States)
Barbara Owczarczak, Roswell Park Cancer Institute (United States)
Patricia Maier, Roswell Park Cancer Institute (United States)

Published in SPIE Proceedings Vol. 6087:
Biophotonics and Immune Responses
Wei R. Chen, Editor(s)

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