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Proceedings Paper

Planar single-molecule sensors based on hollow-core ARROW waveguides
Author(s): Dongliang Yin; John P. Barber; Evan Lunt; Dmitri Ermolenko; Harry Noller; Aaron R. Hawkins; Holger Schmidt
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Paper Abstract

We discuss the development of novel integrated optical sensors with single molecule detection sensitivity. These sensors are based on liquid-core antiresonant reflecting optical waveguides (ARROWs) that allow for simultaneously guiding light and molecules in liquid solution through micron-sized channels on a chip. Using liquid-core ARROWs as the main building block, two-dimensional planar sensor arrays with sensitivity down to the single molecule level can be fabricated. We present the basic design principle for ARROW waveguides and methods to improve waveguide loss. The influence of surface roughness on the waveguide loss is described. We discuss highly efficient fluorescence detection in both one and two dimensional planar waveguide geometries. Avenues towards subsequent integration with microfluidic systems are presented.

Paper Details

Date Published: 1 March 2006
PDF: 13 pages
Proc. SPIE 6125, Silicon Photonics, 61250Q (1 March 2006); doi: 10.1117/12.648570
Show Author Affiliations
Dongliang Yin, Univ. of California, Santa Cruz (United States)
John P. Barber, Brigham Young Univ. (United States)
Evan Lunt, Brigham Young Univ. (United States)
Dmitri Ermolenko, Univ. of California, Santa Cruz (United States)
Harry Noller, Univ. of California, Santa Cruz (United States)
Aaron R. Hawkins, Brigham Young Univ. (United States)
Holger Schmidt, Univ. of California, Santa Cruz (United States)

Published in SPIE Proceedings Vol. 6125:
Silicon Photonics
Joel A. Kubby; Graham T. Reed, Editor(s)

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