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Proceedings Paper

Spatially resolved pharmacokinetic rate images of ICG using near-infrared optical methods
Author(s): Burak Alacam; Birsen Yazici; Xavier Intes; Shoko Nioka; Britton Chance
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Paper Abstract

In this work, we present spatially resolved pharmacokinetic rate images of indocyanine green (ICG) obtained from three breast cancer patients using near infrared imaging methods. We used a two-compartment model, namely, plasma and extracellular extravascular (EES), to model ICG kinetics around the tumor region. We introduced extended Kalman filtering (EKF) framework to estimate the ICG pharmacokinetic rate images. The EKF framework allows simultaneous estimation of pharmacokinetic rates and the ICG concentrations in each compartment. Based on the pharmacokinetic rate images, we observed that the rates from inside and outside the tumor region are statistically different with a p-value of 0.0001 for each patient. Additionally, we observed that the ICG concentrations in plasma and the EES compartments are higher around the tumors agreeing with the hypothesis that ICG may act as a diffusible extravascular flow in leaky capillary of cancer vessels. Our study shows that spatially resolved pharmacokinetic rate images can be potentially useful for breast cancer screening and diagnosis.

Paper Details

Date Published: 22 February 2006
PDF: 10 pages
Proc. SPIE 6088, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV, 60881N (22 February 2006); doi: 10.1117/12.647205
Show Author Affiliations
Burak Alacam, Rensselaer Polytechnic Institute (United States)
Birsen Yazici, Rensselaer Polytechnic Institute (United States)
Xavier Intes, Advanced Research Technologies Inc. (Canada)
Shoko Nioka, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 6088:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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