
Proceedings Paper
Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imagingFormat | Member Price | Non-Member Price |
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Paper Abstract
Small animal models are employed to simulate disease in humans and to study its progression, what factors are
important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic
resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of
diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging
modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of
blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in
spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal
resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by
an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement
each other and cross validation can be performed.
Paper Details
Date Published: 15 February 2006
PDF: 9 pages
Proc. SPIE 6081, Multimodal Biomedical Imaging, 608105 (15 February 2006); doi: 10.1117/12.647138
Published in SPIE Proceedings Vol. 6081:
Multimodal Biomedical Imaging
Fred S. Azar; Dimitris N. Metaxas, Editor(s)
PDF: 9 pages
Proc. SPIE 6081, Multimodal Biomedical Imaging, 608105 (15 February 2006); doi: 10.1117/12.647138
Show Author Affiliations
J. Masciotti, Columbia Univ. (United States)
F. Provenzano, Columbia Univ. (United States)
J. Papa, Columbia Univ. (United States)
A. Klose, Columbia Univ. (United States)
J. Hur, Columbia Univ. (United States)
F. Provenzano, Columbia Univ. (United States)
J. Papa, Columbia Univ. (United States)
A. Klose, Columbia Univ. (United States)
J. Hur, Columbia Univ. (United States)
X. Gu, Columbia Univ. (United States)
D. Yamashiro M.D., Columbia Univ. (United States)
J. Kandel M.D., Columbia Univ. (United States)
A. H. Hielscher, Columbia Univ. (United States)
D. Yamashiro M.D., Columbia Univ. (United States)
J. Kandel M.D., Columbia Univ. (United States)
A. H. Hielscher, Columbia Univ. (United States)
Published in SPIE Proceedings Vol. 6081:
Multimodal Biomedical Imaging
Fred S. Azar; Dimitris N. Metaxas, Editor(s)
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