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Proceedings Paper

Application of colloidal semiconductor quantum dots as fluorescent labels for diagnosis of brain glial cancer
Author(s): Patrícia M. A. Farias; Beate S. Santos; Frederico D. Menezes; Ricardo Ferreira; Fernando J. M. Oliveira Jr.; Hernandes F. Carvalho; Luciana Romão; Vivaldo Moura-Neto; Jane C. O. F. Amaral; Adriana Fontes; Carlos L. Cesar
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Paper Abstract

In this work we present the preparation, characterization and conjugation of colloidal core shell CdS-Cd(OH)2 quantum dots to health and cancer glial rats living cells in culture media. The particles were obtained via colloidal synthesis in aqueous medium, with final pH=7.3-7.4. Laser Scan Confocal Microscopy (LSCM) and Fluorescence Microscopy were used to evaluate fluorescence intensities and patterns of health and cancer (glioblastoma) glial cells labeled with the quantum dots in different time intervals. Health and cancer glial cells clearly differ in their fluorescence intensities and patterns. These different fluorescence intensities and patterns may be associated to differences concerning cellular membrane and metabolic features of health and cancer cells. The results obtained indicate the potential of the methodology for fast and precise cancer diagnostics.

Paper Details

Date Published: 27 March 2006
PDF: 8 pages
Proc. SPIE 6096, Colloidal Quantum Dots for Biomedical Applications, 60961B (27 March 2006); doi: 10.1117/12.646866
Show Author Affiliations
Patrícia M. A. Farias, Univ. Federal de Pernambuco (Brazil)
Beate S. Santos, Univ. Federal de Pernambuco (Brazil)
Frederico D. Menezes, Univ. Federal de Pernambuco (Brazil)
Ricardo Ferreira, Univ. Federal de Pernambuco (Brazil)
Fernando J. M. Oliveira Jr., Secretaria de Saúde do Estado de Pernambuco (Brazil)
Hernandes F. Carvalho, Univ. Estadual de Campinas (Brazil)
Luciana Romão, Univ. Federal do Rio de Janeiro (Brazil)
Vivaldo Moura-Neto, Univ. Federal do Rio de Janeiro (Brazil)
Jane C. O. F. Amaral, Univ. Federal do Rio de Janeiro (Brazil)
Adriana Fontes, Univ. Estadual de Campinas (Brazil)
Carlos L. Cesar, Univ. Estadual de Campinas (Brazil)

Published in SPIE Proceedings Vol. 6096:
Colloidal Quantum Dots for Biomedical Applications
Marek Osinski; Kenji Yamamoto; Thomas M. Jovin M.D., Editor(s)

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