Share Email Print

Proceedings Paper

Mauna Kea technologies’ F400 prototype: a new tool for in vivo microscopic imaging during endoscopy
Author(s): B. Viellerobe; A. Osdoit; C. Cavé; F. Lacombe; S. Loiseau; B. Abrat
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

The purpose of this paper is to demonstrate potential for high resolution fluorescence imaging during standard endoscopic procedures using a catheter-based confocal endoscope, compatible with standard video-endoscopes. The instrument, an F400 prototype from Mauna Kea Technologies (Paris, France), may function in various imaging modalities: auto-fluorescence or exogenous fluorescence using topical applications of fluorophores. The system is composed of a Laser Scanning Unit, a range of fibered objectives and a dedicated software, which makes it possible to obtain images at a rate of 12 frames per second. These images have a lateral resolution of 2.5 microns, an axial resolution of 15 microns, a field of view up to 600 microns x 500 microns and can be obtained at depths up to 100 microns. The miniaturized fibered probes offer unique access capabilities, specifically through the operating channel of an endoscope. So far, these studies have demonstrated the safety and efficacy of the F400 in allowing confocal laser imaging of the internal microstructure of tissues in the anatomical tract accessed by the endoscope, thanks to the miniaturization of the system. The device can be considered as a new tool towards "optical biopsies" and in vivo histology, leading to more physiologically relevant data and cost effective medicine.

Paper Details

Date Published: 23 February 2006
PDF: 11 pages
Proc. SPIE 6082, Endoscopic Microscopy, 60820C (23 February 2006); doi: 10.1117/12.646625
Show Author Affiliations
B. Viellerobe, Mauna Kea Technologies (France)
A. Osdoit, Mauna Kea Technologies (France)
C. Cavé, Mauna Kea Technologies (France)
F. Lacombe, Mauna Kea Technologies (France)
S. Loiseau, Mauna Kea Technologies (France)
B. Abrat, Mauna Kea Technologies (France)

Published in SPIE Proceedings Vol. 6082:
Endoscopic Microscopy
Guillermo J. Tearney M.D.; Thomas D. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?