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Proceedings Paper

Probing molecules by surface-enhanced Raman spectroscopy
Author(s): M. Caterina Netti; M. E. Zoorob; Martin D. B. Charlton; Peter Ayliffe; Sven Mahnkopf; Paul Stopford; K. Todd; John R. Lincoln; Nicolas M. B. Perney; Jeremy J. Baumberg
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Paper Abstract

A new class of Surface-Enhanced Raman Scattering (SERS) substrates have been engineered by exploiting both Photonic Crystal (PC) and semiconductor technologies. Gold coated inverted pyramids nanotextured substrates allow reproducibility <10% and enhancement factors > 106 over large areas. Modelling and optical characterization of the engineered structures is demonstrated. Examples of applications to amino acids and illicit drug detection are given. Concentrations as low as ppm-ppb (mg/mL to ng/mL) have been measured depending on the adsorbed analytes. Information on structure and conformation of the molecule is inferred due to the richer nature of SERS spectra.

Paper Details

Date Published: 27 February 2006
PDF: 12 pages
Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930F (27 February 2006); doi: 10.1117/12.646368
Show Author Affiliations
M. Caterina Netti, Mesophotonics Ltd. (United Kingdom)
M. E. Zoorob, Mesophotonics Ltd. (United Kingdom)
Martin D. B. Charlton, Mesophotonics Ltd. (United Kingdom)
Peter Ayliffe, Mesophotonics Ltd (United Kingdom)
Sven Mahnkopf, Mesophotonics Ltd. (United Kingdom)
Paul Stopford, Mesophotonics Ltd. (United Kingdom)
K. Todd, Mesophotonics Ltd. (United Kingdom)
John R. Lincoln, Mesophotonics Ltd. (United Kingdom)
Nicolas M. B. Perney, Univ. of Southampton (United Kingdom)
Jeremy J. Baumberg, Univ. of Southampton (United Kingdom)

Published in SPIE Proceedings Vol. 6093:
Biomedical Vibrational Spectroscopy III: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang H. Petrich, Editor(s)

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