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Proceedings Paper

Development of the optical biopsy system for small experimental animals
Author(s): Hidetoshi Sato; Yusuke Hattori; Yusuke Oshima; Yuichi Komachi; Takashi Katagiri; Toru Asakura; Toru Shimosegawa; Yuji Matsuura; Mitsunobu Miyagi; Gen'ichi Kanai; Nobuo Ura; Koji Masutani; Hideo Tashiro
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Paper Abstract

Development of the optical biopsy system for experimental small animals is in progress. A prototype of the system which consists of a miniaturized gastro endoscope unit and Raman probes has been completed by now. The system is developed to study a gastric cancer rat model. The endoscope is 2.5 mm in diameter and is equipped an imaging bundle fiber, illumination fibers, a channel and a mechanism to angle the probe head. The head of the Raman probe comes out through the channel and it is possible to aim the probe to the target watching on the monitor. The endoscope was inserted into the anaesthetized healthy rat under the breathing support. It was successfully observed inside of the stomach of the living rat and measured Raman spectra. The spectrum of blood vessels contains the strong contribution from lipids. The present results demonstrate high potential of the system in the in vivo Raman study using the rat model.

Paper Details

Date Published: 22 February 2006
PDF: 5 pages
Proc. SPIE 6091, Optical Biopsy VI, 60910H (22 February 2006); doi: 10.1117/12.645842
Show Author Affiliations
Hidetoshi Sato, RIKEN (Japan)
Yusuke Hattori, RIKEN (Japan)
Yusuke Oshima, RIKEN (Japan)
Yuichi Komachi, RIKEN (Japan)
Machida Endoscope Co., Ltd. (Japan)
Takashi Katagiri, RIKEN (Japan)
Toru Asakura, Tohoku Univ. (Japan)
Toru Shimosegawa, Tohoku Univ. (Japan)
Yuji Matsuura, Tohoku Univ. (Japan)
Mitsunobu Miyagi, Sendai National College of Technology (Japan)
Gen'ichi Kanai, Machida Endoscope Co., Ltd. (Japan)
Nobuo Ura, Soma Opto Co., Ltd. (Japan)
Koji Masutani, Soma Opto Co., Ltd. (Japan)
Hideo Tashiro, RIKEN (Japan)

Published in SPIE Proceedings Vol. 6091:
Optical Biopsy VI
Robert R. Alfano; Alvin Katz, Editor(s)

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