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Proceedings Paper

Real-time broad-band measurement of cholesterol, collagen, and elastin using a novel rotary switch spectrometer
Author(s): Ricardo Claps; Roy Guynn; Wiktor Serafin; Jeff Virojanapa; Aaron Urbas; Robert A. Lodder
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Paper Abstract

The present paper introduces an integrated sensing and processing spectroscopic system that combines Multivariate Factor Analysis (MFA) and Molecular Factor Computation (MFC) with a broad band light source, incorporating a rotary, multichannel optical device to produce real-time, spectroscopic analysis. The system is able to distinguish samples of cholesterol and collagen/elastin within a time range of 25 ms, by using near-infrared reflectance spectroscopy. The potential for the use of the device for in-vivo coronary angiography will be discussed. The system presents several key features that make it unique as a spectroscopic tool: it is compact and rugged with multilayer interference wavelength selection, and capable of operation in high vibration environments. The system is also fast, with the capacity to reduce the measurement delay even further; it is broad band, with a bandwidth limited by the optical source and the sensitivity of the photodetector used; it will allow quantitative, simultaneous, multispecies detection; and it is amenable to different optical delivery/detection schemes. Standard telecommunications-grade parts comprise the system, bridging the gap between the prototype and manufactured product; these include: optical fibers, electrically actuated optical switches, and free-space optics elements. A detailed description of the data analysis algorithm will be presented, with special emphasis on its use for multispecies detection.

Paper Details

Date Published: 22 February 2006
PDF: 18 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60782G (22 February 2006); doi: 10.1117/12.645345
Show Author Affiliations
Ricardo Claps, Neptec Optical Solutions (United States)
Roy Guynn, Neptec Optical Solutions (United States)
Wiktor Serafin, Neptec Optical Solutions (United States)
Jeff Virojanapa, Neptec Optical Solutions (United States)
Aaron Urbas, Univ. of Kentucky (United States)
Robert A. Lodder, Univ. of Kentucky (United States)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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