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Proceedings Paper

Optical spectroscopy of human blood serum albumin interaction with lead ions
Author(s): A. Saha; L. Manglass; S. Lionel; A. Sklyarov; E. Sokol; Yu. M. Petrussevich; G. P. Petrova; V. V. Yakovlev
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Paper Abstract

Lead ions in solution interact strongly with human blood serum albumin forming clusters and modifying electronic properties of albumin molecules. We experimentally demonstrate that this interaction can be detected at pM concentrations of lead in solution. The structural and electronic modifications of albumin were observed using Raman, light scattering, fluorescence, and circular dichroism absorption spectroscopies.

Paper Details

Date Published: 27 February 2006
PDF: 8 pages
Proc. SPIE 6094, Optical Diagnostics and Sensing VI, 60940D (27 February 2006); doi: 10.1117/12.645294
Show Author Affiliations
A. Saha, Univ. of Wisconsin, Milwaukee (United States)
L. Manglass, Univ. of Wisconsin, Milwaukee (United States)
Univ. of Georgia (United States)
S. Lionel, Univ. of Wisconsin, Milwaukee (United States)
A. Sklyarov, Univ. of Wisconsin, Milwaukee (United States)
E. Sokol, Moscow State Univ. (Russia)
Yu. M. Petrussevich, Moscow State Univ. (Russia)
G. P. Petrova, Moscow State Univ. (Russia)
V. V. Yakovlev, Univ. of Wisconsin, Milwaukee (United States)


Published in SPIE Proceedings Vol. 6094:
Optical Diagnostics and Sensing VI
Gerard L. Coté; Alexander V. Priezzhev, Editor(s)

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