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Proceedings Paper

Optical characterization of vocal folds using OCT
Author(s): Kathrin Lüerßen; Holger Lubatschowski; Nicole Radicke; Martin Ptok
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Paper Abstract

The current standard procedure to ensure the diagnosis, if tissue is malignant, is still an invasive one. Optical coherence tomography (OCT) is a new non-invasive method to investigate biological tissue. In this study OCT was used on porcine and on human vocal folds. The optical penetration depth of the used radiation is up to 2 mm. Three different OCT application systems were used. The first is a high resolution OCT, which works in contact mode. It was used to examine porcine vocal folds ex vivo. Porcine vocal folds were assigned to defined areas and examined by OCT in contact mode followed by traditional histo-morphological analysis. The second OCT is fiber based. It also works in contact mode. Images of human vocal folds were done in contact mode. They were compared with a typical histo-morphological image of a human vocal fold. The third application system works in non contact to the tissue. It was integrated in a conventional laryngoscope. Human vocal folds were examined in vivo. Single layers of the vocal folds could be distinguished from each other with all used systems. Pathological alterations could be seen. Imaging is possible in real time. General anaesthesia is not necessary. OCT makes it possible to get a view under the surface of the vocal fold without being invasive.

Paper Details

Date Published: 22 February 2006
PDF: 7 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60781O (22 February 2006); doi: 10.1117/12.645144
Show Author Affiliations
Kathrin Lüerßen, Hanover Medical School (Germany)
Holger Lubatschowski, Laser Zentrum Hannover e.V. (Germany)
Nicole Radicke, Laser Zentrum Hannover e.V. (Germany)
Martin Ptok, Hanover Medical School (Germany)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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