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Proceedings Paper

Atherosclerosis diagnostic imaging by optical spectroscopy and optical coherence tomography
Author(s): M. D. Hewko; L. P. Choo-Smith; A. C. T. Ko; M. S. D. Smith; E. M. Kohlenberg; E. R. Bock; L. Leonardi; M. G. Sowa
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Paper Abstract

Atherosclerosis is traditionally viewed as a disease of uncontrolled plaque growth leading to arterial occlusion. More recently, however, occlusion of the arterial lumen is being viewed as an acute event triggered by plaque rupture and thrombosis. An atheromatous plaque becomes vulnerable to sudden activation and/or rupture when a constellation of processes are activated by various trigger mechanisms. There is growing evidence that the vulnerability (i.e. susceptibility to rupture) and thrombogenic nature of the plaque need to be taken into account in the planning and treatment of the disease. X-ray fluoroscopy and intravascular ultrasound, the current clinical diagnostic tools are not capable of the providing a complete histological picture of the plaque region. Intravascular diagnostic imaging of coronary atherosclerotic plaques by optical means to assess plaque, patient risk and assist in planning treatment strategies represents the future in angioplasty treatment by interventional cardiologists. The techniques which will enable a clinically acceptable and reliable intravascular diagnostic platform are currently being investigated and compared to the clinical standard of histology. Currently, we are investigating the use of a number of optical and imaging techniques for biochemical analysis of arterial tissue including Raman, near infrared and fluorescence spectroscopies. Biochemical imaging will provide compositional information on collagen, elastin, lipid and thrombogenic by-products as well as gauging inflammation and tissue remodeling activity levels. To complement the functional biochemical imaging, optical coherence tomography will be provide structural morphological imaging. The synergistic combination of functional and structural imagery will provide the interventional cardiologist with a complete clinical picture of the atherosclerotic plaque region. The clinician can use this diagnostic information to plan a personalized treatment procedure based on the entire clinical presentation.

Paper Details

Date Published: 22 February 2006
PDF: 11 pages
Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60782E (22 February 2006); doi: 10.1117/12.641438
Show Author Affiliations
M. D. Hewko, National Research Council (Canada)
L. P. Choo-Smith, National Research Council (Canada)
A. C. T. Ko, National Research Council (Canada)
M. S. D. Smith, National Research Council (Canada)
E. M. Kohlenberg, National Research Council (Canada)
E. R. Bock, National Research Council (Canada)
L. Leonardi, National Research Council (Canada)
M. G. Sowa, National Research Council (Canada)

Published in SPIE Proceedings Vol. 6078:
Photonic Therapeutics and Diagnostics II
Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Reza S. Malek M.D.; Michael D. Lucroy D.V.M.; Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Justus F. R. Ilgner M.D.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Haishan Zeng; Guillermo J. Tearney M.D.; Bernard Choi, Editor(s)

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