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Proceedings Paper

Acute phase response induced following tumor treatment by photodynamic therapy: relevance for the therapy outcome
Author(s): Mladen Korbelik; Soroush Merchant; Brandon Stott; Ivana Cecic; Peter Payne; Jinghai Sun
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Paper Abstract

Acute phase response is an effector process orchestrated by the innate immune system for the optimal mobilization of the resources of the organism distant from the local insult site needed in the execution of a host-protecting reaction. Our research has shown that mice bearing tumors treated by photodynamic therapy (PDT) exhibit the three major hallmarks of acute phase response: release of acute phase reactants, neutrophilia, and pituitary/adrenal axis activation. Of particular interest in this study were acute phase proteins that have a pivotal role in the clearance of dead cells, since the occurrence of this process in PDT-treated tumors emerges as a critical event in the course of PDT-associated host response. It is shown that this type of acute phase reactants, including complement proteins (C3, C5, C9, mannose-binding lectin, and ficolin A) and related pentraxins (serum amyloid P component and PTX3), are upregulated following tumor PDT and accumulate in the targeted lesions. Based on the recently accumulated experimental evidence it is definitely established that the acute phase response is manifested in the hosts bearing PDT-treated tumors and it is becoming clear that this effector process is an important element of PDT-associated host response bearing in impact on the eventual outcome of this therapy.

Paper Details

Date Published: 23 February 2006
PDF: 7 pages
Proc. SPIE 6087, Biophotonics and Immune Responses, 60870C (23 February 2006); doi: 10.1117/12.640302
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Agency (Canada)
Soroush Merchant, British Columbia Cancer Agency (Canada)
Brandon Stott, British Columbia Cancer Agency (Canada)
Ivana Cecic, British Columbia Cancer Agency (Canada)
Peter Payne, British Columbia Cancer Agency (Canada)
Jinghai Sun, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 6087:
Biophotonics and Immune Responses
Wei R. Chen, Editor(s)

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