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Proceedings Paper

Effect of intravascular irradiation of He-Ne laser on cerebral infarction: hemorrheology and apoptosis
Author(s): Jian Zhu; Min-yi Liang; Hao-cai Cao; Xiao-Yuan Li; Shao-ming Li; Shun-hao Li; Wen-qi Li; Jin-hong Zhang; Lei Liu; Jian-hong Lai
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Paper Abstract

Objective: To explore the efficacy of He-Ne laser intravascular irradiation on infarction and hemorrheology. To observe the effects of intravascular low level He-Ne laser irradiation (ILLLI) of blood on cell proliferation, apoptosis and chromosome in lymphocyte from cerebral infarction. Methods: Seventy cases with cerebral infarction were randomly divided into groups control group (35 cases) treated only with common drugs and therapeutic group (35 cases) treated besides common drugs also by He-Ne laser intravascular irradiation. Their hemorrheology index and treatment results were observed and compared. The blood lymphocytes of cerebral infarction were cultured before and after treatment. After that, the mitosis index (MI), cell kinetics index (CKI), sister-chromatid exchanges (SCE) frequencies and apoptosis were determined. Results: The therapeutic group was better than the control one. The effective rate in the therapeutic group was 88.6%, in the control one was 65.7%. The viscosity and fibrinogen, etc. were better than that in the control group with significant difference (P<0.01). The lymphocyte proliferation index was significantly two increased than the control one (P>0.05) in cerebral infarction patients after treatment; The CKI of lymphocytes had no obvious difference among groups (P>0.05); SCE frequencies of lymphocytes had no statistic significance between control group and ILLLI on (P>0.05). It showed the apoptosis rate of lymphocytes in cerebral infarction patients after ILLLI treatment increased significantly compared with the control group, (P<0.001). There was a significant difference of apoptosis rate of lymphocytes in cerebral infarction patients than the control (P<0.001). Conclusions: During the He-Ne laser intravascular irradiation of the cerebral infarction, the low level He-Ne by ILLLI can increase the proliferation of lymphocytes, and can induce lymphocytes to apoptosis, but has no mutagenicity of cells.

Paper Details

Date Published: 11 September 2006
PDF: 8 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 59671K (11 September 2006); doi: 10.1117/12.639329
Show Author Affiliations
Jian Zhu, Guangzhou Medical College (China)
Min-yi Liang, Guangzhou Medical College (China)
Hao-cai Cao, Guangzhou Medical College (China)
Xiao-Yuan Li, Zhongshan Medical College, Sun Yat-sen Univ. (China)
Shao-ming Li, Guangzhou Medical College (China)
Shun-hao Li, Guangzhou Medical College (China)
Wen-qi Li, Guangzhou Medical College (China)
Jin-hong Zhang, Guangzhou Medical College (China)
Lei Liu, Guangzhou Medical College (China)
Jian-hong Lai, Guangzhou Medical College (China)

Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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