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Proceedings Paper

Photodynamic therapy for implanted VX2 tumor in rabbit brains
Author(s): Fei Li; Hua Feng; Jiangkai Lin; Gang Zhu; Zhi Chen; Cong-yan Li
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Paper Abstract

To evaluate the therapeutic effect and the safety of single photodynamic therapy (PDT) with hematoporphyrin derivative produced in China, 60 New Zealand adult rabbits with VX2 tumor implanted into the brain were divided randomly into non-PDT-group and PDT-group. 36 rabbits of the PDT-group were performed photodynamic therapy. The survival time, neurological deteriorations, intracranial pressure (ICP), histology, pathology, tumor volume and brain water content were measured. Other 12 rabbits were received hematoporphyrin derivative and light irradiation of the normal brain. The ICP, histology, pathology, and brain water content were measured. The result indicated that Simple PDT may elongate the average survival time of the rabbits with VX2 tumors significantly; kill tumor cells; cause transient brain edema and increase ICP, but it is safe to be used in treating brain tumor.

Paper Details

Date Published: 11 September 2006
PDF: 11 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596711 (11 September 2006); doi: 10.1117/12.639236
Show Author Affiliations
Fei Li, Third Military Medical Univ. (China)
Hua Feng, Third Military Medical Univ. (China)
Jiangkai Lin, Third Military Medical Univ. (China)
Gang Zhu, Third Military Medical Univ. (China)
Zhi Chen, Third Military Medical Univ. (China)
Cong-yan Li, Chongqing Medical Univ. (China)

Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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