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Proceedings Paper

Mechanisms of tumor destruction caused by photodynamic therapy
Author(s): Chuannong Zhou
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Paper Abstract

Photodynamic therapy is a relatively new treatment modality and is becoming widely accepted as a standard treatment of a variety of solid tumors. This includes palliative treatments for advanced or obstructive cancers in many organs as well as a curative treatment for some early cancers and pre-cancerous lesions. It has been approved by health authorities in a number of countries in America, Europe and Asia. PDT is a procedure requiring 3 elements: photosensitizer, light and oxygen. The typical technique involves an intravenous administration of a photosensitizing agent, which is preferentially accumulated or retained in tumor tissue, followed by irradiation of the tumor area with light of appropriate wavelength. In the presence of oxygen it generates highly reactive and cytotoxic molecular species, in particular, singlet oxygen (1O2), which may oxidize various bio-molecules and finally leading to cell death and tumor destruction. The most widely used photosensitizer in clinical treatment of cancers is Photofrin (porfimer sodium), and most widely used light sources are lasers of various types, in recent years preferentially, diode laser, which emits a red light of 630 nm wavelength.

Paper Details

Date Published: 11 September 2006
PDF: 7 pages
Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596706 (11 September 2006);
Show Author Affiliations
Chuannong Zhou, Cancer Institute, Chinese Academy of Medical Sciences (China)

Published in SPIE Proceedings Vol. 5967:
2004 Shanghai International Conference on Laser Medicine and Surgery
Jing Zhu, Editor(s)

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