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Proceedings Paper

Estimation of contribution of multiple scattering into the optical coherence tomography signal from layers of different biological tissues
Author(s): Marina S. Fedosseeva; Mikhail Yu. Kirillin; Alexander V. Priezzhev; Risto Myllyla
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Paper Abstract

Optical coherence tomography (OCT) signals from blood layers (thickness of 0.5 mm) for the haematocrits of 35, 10 and 5%, intralipid (thickness of 2 mm) for 10, 5 and 2% concentrations, as well as from upper skin layers (stratum corneum and epidermis) for the thicknesses of 120, 135 and 150 jim were simulated using Monte-Carlo method. For blood and intralipid simulations the wavelength was chosen equal to 820 nm and for upper skin layers simulation equal to 630 nm. The coherence length was assumed to be 15 Iim. The contribution of multiple scattering to OCT was analyzed for the models under study. It was shown that for blood the percentage ofmultiple scattering contribution in to the signal increases as haematocrit goes up: for 5%-haematocrit the contribution is less than 1%, for 10%-haematocrit about 4.5%, and for 35% - some 64%. It appears that for intralipid the major contribution to the signal for all the concentrations under consideration is made by multiple scattering: for 2%-concentration - about 44.5%, for 5%-concentration -72%, and for 10%-concentration - more than 85%. Apparently, for skin surface layers the multiple scattering contribution rises as the layer thickness increases: as the layer thickness is varied from 20 to 50 im the multiple scattering contribution varies from 14 to 74%.

Paper Details

Date Published: 22 June 2005
PDF: 8 pages
Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); doi: 10.1117/12.634665
Show Author Affiliations
Marina S. Fedosseeva, M.V. Lomonosov Moscow State Univ. (Russia)
Mikhail Yu. Kirillin, M.V. Lomonosov Moscow State Univ. (Russia)
Univ. of Oulu (Finland)
Alexander V. Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Risto Myllyla, Univ. of Oulu (Finland)

Published in SPIE Proceedings Vol. 5771:
Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI
Valery V. Tuchin, Editor(s)

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