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Proceedings Paper

Nano-scale chemical and biological sensors
Author(s): Sven Moller; Garry D. Hinch; Kenneth J. Duda; Pavel Kornilovitch; Kevin F. Peters; Kenneth Ward; Qingqiao Wei; Xioafeng Yang
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Paper Abstract

Nano-engineered devices with potential for trace level detection of chemical or biological species are investigated. The sensor system is a ChemFET device based on micro- and nano-scale silicon wires. The sensor response to changes in pH reveals a significantly higher sensitivity of nano-scale devices compared to micro-scale devices. By immobilizing DNA probe molecules on the silicon wire surface, the ChemFET devices are rendered specific to this DNA sequence. Differential measurements minimize the effects of non-specific binding. At a concentration of CDNA=10μM, two different single stranded 24-base DNA oligonucleotides have been clearly distinguished in the sensor response. DNA hybridization on the silicon wire surface is further corroborated by fluorescence spectroscopy and analysis of characteristic time constants in the sensors response.

Paper Details

Date Published: 17 November 2005
PDF: 12 pages
Proc. SPIE 6008, Nanosensing: Materials and Devices II, 60080I (17 November 2005); doi: 10.1117/12.634534
Show Author Affiliations
Sven Moller, Hewlett Packard Co. (United States)
Garry D. Hinch, Hewlett Packard Co. (United States)
Kenneth J. Duda, Hewlett Packard Co. (United States)
Pavel Kornilovitch, Hewlett Packard Co. (United States)
Kevin F. Peters, Hewlett Packard Co. (United States)
Kenneth Ward, Hewlett Packard Co. (United States)
Qingqiao Wei, Hewlett Packard Co. (United States)
Xioafeng Yang, Hewlett Packard Co. (United States)

Published in SPIE Proceedings Vol. 6008:
Nanosensing: Materials and Devices II
M. Saif Islam; Achyut K. Dutta, Editor(s)

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