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Proceedings Paper

Infrared free electron laser enhanced transdermal drug delivery
Author(s): Kunio Awazu; Takeyuki Uchizono; Sachiko Suzuki; Kazushi Yoshikawa
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Paper Abstract

It is necessary to control enhancement of transdermal drug delivery with non-invasive. The present study was investigated to assess the effectivity of enhancing the drug delivery by irradiating 6-μm region mid infrared free electron laser (MIR-FEL). The enhancement of transdermal drug (lidocaine) delivery of the samples (hairless mouse skin) irradiated with lasers was examined for flux (μg/cm2/h) and total penetration amount (μg/cm2) of lidocaine by High performance Liquid Chromatography (HPLC). The flux and total amount penatration date was enhanced 200-300 fold faster than the control date by the laser irradiation. FEL irradiating had the stratum corneum, and had the less thermal damage in epidermis. The effect of 6-μm region MIR-FEL has the enhancement of transdermal drug delivery without removing the stratum corneum because it has the less thermal damage. It leads to enhancement drug delivery system with non-invasive laser treatment.

Paper Details

Date Published: 26 August 2005
PDF: 8 pages
Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630N (26 August 2005);
Show Author Affiliations
Kunio Awazu, Osaka Univ. (Japan)
Takeyuki Uchizono, Osaka Univ. (Japan)
Sachiko Suzuki, Osaka Univ. (Japan)
Kazushi Yoshikawa, Osaka Dental Univ. (Japan)


Published in SPIE Proceedings Vol. 5863:
Therapeutic Laser Applications and Laser-Tissue Interactions II
Hubert van den Bergh; Alfred Vogel, Editor(s)

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