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Proceedings Paper

Indocyanine green-laser thermolysis of acne vulgaris
Author(s): Elina A. Genina; Alexey N. Bashkatov; Georgy V. Simonenko; Valery V. Tuchin; Ilya V. Yaroslavsky; Gregory B. Altshuler
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Paper Abstract

The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy and photothermolysis. In application to skin appendages a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine Green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser photothermolysis in combination with topical application of ICG suggested for treatment of acne vulgaris. Two volunteers with back-located acne were enrolled. Skin sites of subjects were stained by ICG and irradiated by NIR laser-diode light (803 or 809 nm). The individual acne lesions were photothermally treated at 18 W/cm2 (803 nm, 0.5 sec) without skin surface cooling or at 200 W/cm2 (809 nm, 0.5 sec) with cooling. The results of the observations during a month after the treatment have shown that ICG stained acne inflammatory elements were destructed for light exposures of 0.5 sec.

Paper Details

Date Published: 26 August 2005
PDF: 7 pages
Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630L (26 August 2005); doi: 10.1117/12.633088
Show Author Affiliations
Elina A. Genina, Saratov State Univ. (Russia)
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Georgy V. Simonenko, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)
Ilya V. Yaroslavsky, Palomar Medical Technologies, Inc. (United States)
Gregory B. Altshuler, Palomar Medical Technologies, Inc. (United States)

Published in SPIE Proceedings Vol. 5863:
Therapeutic Laser Applications and Laser-Tissue Interactions II
Hubert van den Bergh; Alfred Vogel, Editor(s)

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