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Proceedings Paper

Influence of the excitation wavelength on the tumor-to-healthy contrast in autofluorescence bronchoscopy: a comprehensive study
Author(s): Tanja Gabrecht; Pascal Uehlinger; Snezana Andrejevic; Pierre Grosjean; Alexandre Radu; Philippe Monnier; Bernd-Claus Weber; Hubert van den Bergh; Georges Wagnieres
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Paper Abstract

Autofluorescence (AF) bronchoscopy is a useful tool for early cancer detection. However the mechanisms involved in this diagnosis procedure are poorly understood. We present an in vivo autofluorescence imaging study to access the depth of the principal contrast mechanisms within the bronchial tissue comparing a narrow band and broad band violet fluorescence excitation. Knowledge of this parameter is crucial for the optimization of the spectral and optical design of clinical diagnostic AF imaging devices. We observed no differences in the chromatic contrast using the two excitation modes, indicating that the principal contrast mechanisms have a non-superficial character.

Paper Details

Date Published: 7 October 2005
PDF: 6 pages
Proc. SPIE 5862, Diagnostic Optical Spectroscopy in Biomedicine III, 586207 (7 October 2005); doi: 10.1117/12.633009
Show Author Affiliations
Tanja Gabrecht, Swiss Federal Institute of Technology (EPFL) (Switzerland)
Pascal Uehlinger, Swiss Federal Institute of Technology (EPFL) (Switzerland)
Snezana Andrejevic, The CHUV Univ. Hospital (Switzerland)
Pierre Grosjean, The CHUV Univ. Hospital (Switzerland)
Alexandre Radu, The CHUV Univ. Hospital (Switzerland)
Philippe Monnier, The CHUV Univ. Hospital (Switzerland)
Bernd-Claus Weber, Richard Wolf Endoskope GmbH (Germany)
Hubert van den Bergh, Swiss Federal Institute of Technology (EPFL) (Switzerland)
Georges Wagnieres, Swiss Federal Institute of Technology (EPFL) (Switzerland)

Published in SPIE Proceedings Vol. 5862:
Diagnostic Optical Spectroscopy in Biomedicine III
Mary-Ann Mycek, Editor(s)

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