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Proceedings Paper

Ultrahigh resolution optical coherence tomography of human skin
Author(s): B. Povazay; A. Unterhuber; B. Hermann; S. Gasparoni; H. Kittler; H. Sattmann; F. Roka; M. Binder; K. Bizheva; R. Leitgeb; H. Pehamberger; W. Drexler
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Paper Abstract

Ultrahigh resolution OCT (UHR OCT) was performed on normal and pathologic human skin biopsies using an ultrabroad-bandwidth (260 nm) Titanium:sapphire laser, enabling sub-micrometer (0.9 μm) axial UHR OCT resolution. Penetration, image contrast as well as resolution capabilities achieved are analyzed for optimum UHR OCT in vivo performance. With the achieved resolution and the penetration depth, the transition between the dermis and the epidermis is clearly visible by UHR OCT, and also the anomalies of pathologies, which have been confirmed performing a comparison with histological analysis. Three dimensional UHR OCT of normal skin is demonstrated with less than 3 μm axial resolution at video-rate with up to 50 B-scans/second, each tomogram consisting of 512×1024 pixels, resulting in 25 Megavoxels/second.

Paper Details

Date Published: 7 October 2005
PDF: 4 pages
Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610R (7 October 2005); doi: 10.1117/12.632985
Show Author Affiliations
B. Povazay, Medical Univ. Vienna (Austria)
A. Unterhuber, Medical Univ. Vienna (Austria)
B. Hermann, Medical Univ. Vienna (Austria)
S. Gasparoni, Medical Univ. Vienna (Austria)
H. Kittler, Medical Univ. Vienna (Austria)
H. Sattmann, Medical Univ. Vienna (Austria)
F. Roka, Medical Univ. Vienna (Austria)
M. Binder, Medical Univ. Vienna (Austria)
K. Bizheva, Medical Univ. Vienna (Austria)
R. Leitgeb, Medical Univ. Vienna (Austria)
H. Pehamberger, Medical Univ. Vienna (Austria)
W. Drexler, Medical Univ. Vienna (Austria)

Published in SPIE Proceedings Vol. 5861:
Optical Coherence Tomography and Coherence Techniques II
Wolfgang Drexler, Editor(s)

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