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Proceedings Paper

Applications of surface-enhanced Raman spectroscopy (SERS) for biosensing: an analysis of reproducible commercially available substrates
Author(s): Troy A. Alexander
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Paper Abstract

The rapid and accurate determination of bacterial spores in sterile environments (i.e., food preparation areas and hospitals) is of great importance in the minimization of bacteria-driven illnesses. Surface- Enhanced-Raman-Scattering (SERS) is potentially a very sensitive spectroscopic technique for the detection of biological threat agents. SERS can be made a more robust and attractive spectroscopic technique for biological threat agent sensing by developing high sensitivity, high reproducibility SERS-active substrates. The maturation of Si-based semiconductor fabrication techniques has facilitated the development and marketing of highly reproducible and sensitive SERS-active substrates. KlariteTM SERS-active substrates (Mesophotonics LTD) have been analyzed for utility in the potential identification of biological threat agents. Concurrently, we have investigated prototype SERS- active substrates under development by Nanospectra Biosciences, Inc. Substrate spatial reproducibility and substrate-to-substrate reproducibility will be discussed.

Paper Details

Date Published: 10 November 2005
PDF: 8 pages
Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 600703 (10 November 2005);
Show Author Affiliations
Troy A. Alexander, U.S. Army Research Lab. (United States)

Published in SPIE Proceedings Vol. 6007:
Smart Medical and Biomedical Sensor Technology III
Brian M. Cullum; J. Chance Carter, Editor(s)

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