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Proceedings Paper

Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases
Author(s): Margarete K. Akens D.V.M.; Albert J. M. Yee M.D.; Lothar Lilge; Shane Burch M.D.; Cari Whyne; Brian C Wilson; Stuart K. Bisland
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Paper Abstract

Photodynamic therapy (PDT) as a non-radiative treatment has been applied successfully in various cancers. PDT may be a useful adjunct in the treatment of vertebral metastases. PDT efficacy requires the administration of a photosensitiser drug followed by subsequent drug activation by wavelength specific light. The study purpose was to establish the pharmacokinetic profiles for 2 photosensitisers, BPD-MA and 5-ALA induced PpIX, to determine the optimal drug-light interval for vertebral PDT.

Paper Details

Date Published: 3 December 2007
PDF: 4 pages
Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596917 (3 December 2007); doi: 10.1117/12.628730
Show Author Affiliations
Margarete K. Akens D.V.M., Sunnybrook and Women's College Health Science Ctr. (Canada)
Univ. Health Network (Canada)
Albert J. M. Yee M.D., Sunnybrook and Women's College Health Science Ctr. (Canada)
Lothar Lilge, Univ. Health Network (Canada)
Shane Burch M.D., Univ. of California/San Francisco (United States)
Cari Whyne, Sunnybrook and Women's College Health Science Ctr. (Canada)
Brian C Wilson, Univ. Health Network (Canada)
Stuart K. Bisland, Univ. Health Network (Canada)

Published in SPIE Proceedings Vol. 5969:
Photonic Applications in Biosensing and Imaging
Brian C. Wilson; Richard I. Hornsey; Warren C. W. Chan; Ulrich J. Krull; Robert A. Weersink; Kui Yu, Editor(s)

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