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Proceedings Paper

Imaging tissue microstructure and microvasculature with Doppler optical coherence tomography: 3-dimensional flow phantom study
Author(s): Beau A. Standish; Daina Burnes; Stephanie Chiu; Nigel R Munce; Linda Mao; Victor X. D. Yang; I. Alex Vitkin
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Paper Abstract

Time domain Doppler optical coherence tomography (DOCT) is a promising non-invasive imaging system with high spatial (~20μm) and velocity resolution (~20μm/s) that can image microvascular blood flow. It is important to understand and account for the complicated 3D nature of small blood vessels. To address this problem, two realistic flow phantoms were designed with known geometries -- an occluded flow path to model vessel narrowing, and a Y-bifurcation to simulate vessel branching. The current DOCT system produces 2D images, which when stacked sequentially can yield 3D images of microstructure and perfusion-level blood flow. 3D reconstructions allow the investigation of internal flow profiles, including an abrupt stenosis in the occluded phantom. This research will help guide our image interpretation of in-vivo DOCT studies, including treatment response monitoring in animal tumours and endoscopic assessment of the human GI tract.

Paper Details

Date Published: 13 October 2005
PDF: 8 pages
Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691R (13 October 2005); doi: 10.1117/12.628581
Show Author Affiliations
Beau A. Standish, Univ. of Toronto (Canada)
Daina Burnes, Univ. of Guelph (Canada)
Stephanie Chiu, Ontario Cancer Institute/Univ. Health Network (Canada)
Nigel R Munce, Univ. of Toronto (Canada)
Linda Mao, Ontario Cancer Institute/Univ. Health Network (Canada)
Victor X. D. Yang, Ontario Cancer Institute/Univ. Health Network (Canada)
Ryerson Univ. (Canada)
I. Alex Vitkin, Univ. of Toronto (Canada)
Radiation Oncology (Canada)
Ontario Cancer Institute/Univ. Health Network (Canada)

Published in SPIE Proceedings Vol. 5969:
Photonic Applications in Biosensing and Imaging
Brian C. Wilson; Richard I. Hornsey; Warren C. W. Chan; Ulrich J. Krull; Robert A. Weersink; Kui Yu, Editor(s)

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