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Proceedings Paper

Infrared spectroscopy of biofluids: from the research lab to the clinical lab
Author(s): Sarah Low Ying; Angela Man; Jaclyn Harris; R. Anthony Shaw
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Paper Abstract

Infrared spectroscopy is well established as an analytical technique in various applications. We have undertaken a series of studies to establish the suitability of mid infrared spectroscopy in various clinical analytical applications, focusing on various urine, serum and whole blood assays. The initial work demonstrated that six common serum analyses are possible, namely glucose, urea, total cholesterol, triglycerides, total protein, and albumin, with accuracy comparable to standard clinical methods (Hitachi 717), and more recently HDL and LDL cholesterol have been quantified separately. Herein, we summarize our progress in transferring this technology to the clinical laboratory, focusing on the new methods and hardware that have enabled this transition, assessing the accuracy of the mid IR based analytical methods using these innovations, and reporting an exploratory study assessing the transferability of methods between spectrometers.

Paper Details

Date Published: 13 October 2005
PDF: 10 pages
Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 59691P (13 October 2005); doi: 10.1117/12.627697
Show Author Affiliations
Sarah Low Ying, National Research Council of Canada (Canada)
Angela Man, National Research Council of Canada (Canada)
Jaclyn Harris, National Research Council of Canada (Canada)
R. Anthony Shaw, National Research Council of Canada (Canada)

Published in SPIE Proceedings Vol. 5969:
Photonic Applications in Biosensing and Imaging
Brian C. Wilson; Richard I. Hornsey; Warren C. W. Chan; Ulrich J. Krull; Robert A. Weersink; Kui Yu, Editor(s)

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