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Proceedings Paper

Photoacoustic spectroscopy application in diffusion examinations
Author(s): Jerzy Bodzenta; Bui Duc Hanh; Anna Kazmierczak; Reinhard H. H. Neubert; Siegfrid Wartewig
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Paper Abstract

Based on Fick's second law the problem of drug diffusion into a membrane was solved. Spatial and time dependent distribution of the drug in the membrane was described analytically. Comparison of obtained solution with experimental results from infrared attenuated total reflectance studies of dithranol diffusion into the dodecanol-collodion membrane confirmed correctness of the theory. Based on a model describing the concentration of diffusing matter it was possible to calculate numerically the photoacoustic signal arising when the membrane was illuminated by modulated light. Detailed numerical analysis showed that photoacoustic spectroscopy (PAS) can be used in experimental investigation of diffusion, but some limitations connected with optical parameters of diffusing matter and the membrane must be taken into account. Proposed mathematical model was used for interpretation of experimental data from "classical" PAS measurement in UV range and step-scan Fourier-transform infrared PAS. Experiments were carried out for diffusion of: dithranol, ketoconazole and methoxalen. Using a multiparameter fitting procedure one has determined diffusion coefficient of enumerated drugs in dodecanol-collodion membrane. Obtained results confirmed usability of PAS technique for studies of diffusion processes.

Paper Details

Date Published: 29 September 2005
PDF: 11 pages
Proc. SPIE 5953, Acousto-optics and Photoacoustics, 595309 (29 September 2005); doi: 10.1117/12.621858
Show Author Affiliations
Jerzy Bodzenta, Silesian Univ. of Technology (Poland)
Bui Duc Hanh, Martin-Luther Univ. (Germany)
Anna Kazmierczak, Silesian Univ. of Technology (Poland)
Reinhard H. H. Neubert, Martin-Luther Univ. (Germany)
Siegfrid Wartewig, Institute of Applied Dermatopharmacy (Germany)

Published in SPIE Proceedings Vol. 5953:
Acousto-optics and Photoacoustics
Antoni Sliwinski; Rainer Reibold; Vitaly B. Voloshinov, Editor(s)

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