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Proceedings Paper

Mitochondrial correlation as a biophotonic marker for detecting cancer in a single cell
Author(s): Paul Lee Gourley; Judy Kay Hendricks; Anthony E. McDonald; R. Guild Copeland; Keith E. Barrett; Cheryl R. Gourley; Robert K. Naviaux
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Paper Abstract

Currently, pathologists rely on labor-intensive microscopic examination of tumor cells using century-old staining methods that can give false readings. Emerging BioMicroNanotechnologies have the potential to provide accurate, realtime, high throughput screening of tumor cells without invasive chemical reagents. These techniques are critical to advancing early detection, diagnosis, and treatment of disease. Using our award-winning Hyperspectral Inceptor to rapidly assess the properties of cells flown through a micro/nano semiconductor device, we discovered a method to rapidly assess the health of a single mammalian cell. The key discovery was the elucidation of biophotonic differences in normal and cancer cells by using intracellular mitochondria as biomarkers for disease. This technique holds promise for detecting cancer at a very early stage and could nearly eliminate delays in diagnosis and treatment.

Paper Details

Date Published: 29 March 2005
PDF: 12 pages
Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); doi: 10.1117/12.612072
Show Author Affiliations
Paul Lee Gourley, Sandia National Labs. (United States)
Judy Kay Hendricks, Sandia National Labs. (United States)
Anthony E. McDonald, Sandia National Labs. (United States)
R. Guild Copeland, Sandia National Labs. (United States)
Keith E. Barrett, Sandia National Labs. (United States)
Cheryl R. Gourley, Sandia National Labs. (United States)
Robert K. Naviaux, Univ. of California/San Diego (United States)

Published in SPIE Proceedings Vol. 5699:
Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III
Dan V. Nicolau; Dan V. Nicolau; Jörg Enderlein; Ramesh Raghavachari; Robert C. Leif; Daniel L. Farkas, Editor(s)

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