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Proceedings Paper

Distribution of DNA fragment sizes after irradiation with heavy ions
Author(s): Ewa Gudowska-Nowak; Katarzyna Psonka; Stephan Brons; Gisela Taucher-Scholz
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Paper Abstract

Ionizing radiation is responsible for production of double strand breaks (DSB) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses minimalistic models that describe observable pattern of distribution of fragment lengths in DNA segments irradiated with heavy ions and applies the formalism to interpret the recent experimental data collected by use of the atomic force microscope (AFM).

Paper Details

Date Published: 23 May 2005
PDF: 7 pages
Proc. SPIE 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III, (23 May 2005); doi: 10.1117/12.611827
Show Author Affiliations
Ewa Gudowska-Nowak, Jagiellonian Univ. (Poland)
Gesellschaft fur Schwerionenforschung mbH (Germany)
Katarzyna Psonka, Jagiellonian Univ. (Poland)
Stephan Brons, Gesellschaft fur Schwerionenforschung mbH (Germany)
Gisela Taucher-Scholz, Gesellschaft fur Schwerionenforschung mbH (Germany)

Published in SPIE Proceedings Vol. 5841:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III
Nigel G. Stocks; Derek Abbott; Robert P. Morse, Editor(s)

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