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Proceedings Paper

Hydrophobic chalcogenide fibers for cell-based bio-optical sensors
Author(s): Pierre Lucas; Mark R. Riley; Michelle A. Solis; Christophe Juncker; Jayne Collier; Dianne E. Boesewetter
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Paper Abstract

Chalcogenide fibers are shown to exhibit a hydrophobic surface behavior which results in detection enhancement for organic species in aqueous solutions. We use these fibers to monitor the infrared signature of human lung cells and detect the presence of toxic agents in the cell surrounding media. The signal is collected using a fiber evanescent wave spectroscopy set up with live human cells acting as a sensitizer for detection of minute quantities of toxicant. A monolayer of human alveolar epithelial cells form strong attachment at the surface of the fiber sensing zone and live in contact with the fiber while their IR spectra is collected remotely. Biochemical change in the living cells are detected during exposure to toxic agents. Variations in the spectroscopic features of the cells are observed in different spectral regions. Finally, the toxicity of Te2As3Se5 fibers is investigated.

Paper Details

Date Published: 23 March 2005
PDF: 11 pages
Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); doi: 10.1117/12.610828
Show Author Affiliations
Pierre Lucas, Univ. of Arizona (United States)
Mark R. Riley, Univ. of Arizona (United States)
Michelle A. Solis, Univ. of Arizona (United States)
Christophe Juncker, Univ. of Arizona (United States)
Jayne Collier, Univ. of Arizona (United States)
Dianne E. Boesewetter, Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 5691:
Optical Fibers and Sensors for Medical Applications V
Israel Gannot, Editor(s)

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