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Proceedings Paper

Physics behind the new technique "Sensing of phage-triggered ion cascades" (SEPTIC) for the prompt identification of bacteria
Author(s): L. B. Kish; Sergey M. Bezrukov; A. Der; M. Cheng; M. D. King; R. Young; S. Seo; J. Kim
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Paper Abstract

Fatal injury of bacteria opens transmembrane ion pathways that create temporary ion clouds around the cells. This ion release transiently charges bacteria yielding spatiotemporal fluctuations of the electrical field which show up like a "fatal scream" in thermal noise. The effect has recently been demonstrated with the specific injuries caused by bacteriophage infections (King, et al, in press) and suggested for identification of bacteria with extraordinary speed and selectivity. Calculations indicate that the detection and identification of a single bacterium can be achieved with natural (wild) phages with reasonable efforts within a time window of 10 minutes. However the potential applicability of the agent-triggered ion cascade reaches much beyond that, including other kinds of injuries, such as those induced by antibiotics, ageing, poisoning, etc. Considerations and open questions about the physical aspects of the fluctuations and their detectability are discussed in this talk.

Paper Details

Date Published: 23 May 2005
PDF: 4 pages
Proc. SPIE 5846, Noise and Information in Nanoelectronics, Sensors, and Standards III, (23 May 2005); doi: 10.1117/12.610671
Show Author Affiliations
L. B. Kish, Texas A&M Univ. (United States)
Sergey M. Bezrukov, National Institutes of Health (United States)
A. Der, Institute of Biophysics, Biology Research Ctr. (Hungary)
M. Cheng, Texas A&M Univ. (United States)
M. D. King, Texas A&M Univ. (United States)
R. Young, Texas A&M Univ. (United States)
S. Seo, Texas A&M Univ. (United States)
J. Kim, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 5846:
Noise and Information in Nanoelectronics, Sensors, and Standards III
Janos A. Bergou; Janusz M. Smulko; Mark I. Dykman; Lijun Wang, Editor(s)

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