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Proceedings Paper

Improved photosensitizers for photodynamic therapy
Author(s): Ravindra K. Pandey; Fuu-Yau Shiau; Isabelle Meunier; Subbaraya Ramaprasad; Adam B. Sumlin; Thomas J. Dougherty; Kevin M. Smith
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Paper Abstract

In order to evaluate the effect of substituents in photosensitizing activity, a series of long wavelength absorbing photosensitizers related to pyropheophorbides, bacteriopheophorbides, and benzoporphyrin derivatives were synthesized. Pheophorbide dimers, covalently joining two molecules of pyropheophorbide-a and bacteriopheophorbide-a with lysine as a cross-link were also prepared. The syntheses and spectroscopic properties of these compounds are discussed. Some of these compounds were tested for in vivo photosensitizing activity vis-a-vis Photofrin IITM, using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. The preliminary in vivo results suggest that replacement of substituents at peripheral positions of the macrocycles causes a significant difference in photosensitizing efficacy.

Paper Details

Date Published: 1 June 1992
PDF: 10 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60948
Show Author Affiliations
Ravindra K. Pandey, Univ. of California/Davis and Roswell Park Cancer Institute (United States)
Fuu-Yau Shiau, Univ. of California/Davis (United States)
Isabelle Meunier, Univ. of California/Davis (United States)
Subbaraya Ramaprasad, Univ. of Arkansas for Medical Sciences (United States)
Adam B. Sumlin, Roswell Park Cancer Institute (United States)
Thomas J. Dougherty, Roswell Park Cancer Institute (United States)
Kevin M. Smith, Univ. of California/Davis (United States)

Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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