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Proceedings Paper

Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers
Author(s): Benjamin Ehrenberg; Adina Lavi; Yeshayahu Nitzan; Zvi Malik; Hava Ladan; Fred M. Johnson; Jonathan L. Sessler
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Paper Abstract

Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg2+ and Zn2+-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

Paper Details

Date Published: 1 June 1992
PDF: 5 pages
Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); doi: 10.1117/12.60947
Show Author Affiliations
Benjamin Ehrenberg, Bar-Ilan Univ. (Israel)
Adina Lavi, Bar-Ilan Univ. (Israel)
Yeshayahu Nitzan, Bar-Ilan Univ. (Israel)
Zvi Malik, Bar-Ilan Univ. (Israel)
Hava Ladan, Bar-Ilan Univ. (Israel)
Fred M. Johnson, California State Univ./Fullerton (United States)
Jonathan L. Sessler, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 1645:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy
Thomas J. Dougherty, Editor(s)

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