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Proceedings Paper

Observation of a power law memory kernel for distance fluctuation within a single protein molecule
Author(s): Wei Min; Guobin Luo; Binny J. Cherayil; Samuel C. Kou; X. Sunney Xie
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Paper Abstract

The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photo-induced electron transfer, and found to be a stationary, time-reversible and non-Markovian Gaussian process. Within the generalized Langevin equation (GLE) formalism, we experimentally determine the memory kernel, K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t- 0.51 ± 0.07 in a broad range of time-scales (10-3 s -10s. Such a long time memory effect, which is associated with sub-diffusion within a harmonic bound, has implications to protein functions.

Paper Details

Date Published: 23 May 2005
PDF: 11 pages
Proc. SPIE 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III, (23 May 2005); doi: 10.1117/12.608514
Show Author Affiliations
Wei Min, Harvard Univ. (United States)
Guobin Luo, Harvard Univ. (United States)
Binny J. Cherayil, Harvard Univ. (United States)
Samuel C. Kou, Harvard Univ. (United States)
X. Sunney Xie, Harvard Univ. (United States)

Published in SPIE Proceedings Vol. 5841:
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III
Nigel G. Stocks; Derek Abbott; Robert P. Morse, Editor(s)

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