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Proceedings Paper

System design considerations for an x-ray phase-contrast imaging system based on in-line holography
Author(s): Xizeng Wu; Hong Liu; Aimin Yan
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Paper Abstract

Since Roentgen discovered x-ray and performed the first x-ray imaging more than 100 years ago, x-ray imaging has always been based on the biological tissue's differences in x-ray attenuation. However, x-ray-tissue interaction causes x-ray phase changes as well, and the tissue’s differences in phase are about one thousand times larger than their differences in x-ray attenuation. We will present the theoretical foundation and design considerations for clinical x-ray phase-contrast imaging systems based on the x-ray in-line holography. Different from the analysis in literature, we proposed a new formalism for in-line phase-contrast imaging to analyze the effects of four clinically important factors on the phase-contrast. These are the body parts attenuation, the spatial coherence of incident x-ray from an x-ray tube, polychromatic x-ray and radiation dose to patients for clinical applications. We will discuss the phase image-reconstruction based on our new theory for the x-ray in-line holography as well. The theory and image reconstruction algorithms presented in this paper can be applied widely to the diagnostic x-ray imaging applications. The phase-contrast imaging system design guidelines based on the new theory will be discussed and its validation by the computer simulations will be demonstrated.

Paper Details

Date Published: 18 January 2005
PDF: 11 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.605350
Show Author Affiliations
Xizeng Wu, Univ. of Alabama/Birmingham (United States)
Hong Liu, Univ. of Oklahoma (United States)
Aimin Yan, Univ. of Alabama/Birmingham (United States)

Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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