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Proceedings Paper

Modeling the effect of p53 on tumor heterogeneity and the mutator phenotype
Author(s): Melissa Ryan; Matthew J. Berryman; Derek Abbott
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Paper Abstract

p53 is an important gene, involved in apoptosis (programmed cell death), DNA repair, and cell cycle progression. We explore the selective advantages and disadvantages of mutations in the p53 gene on tumor cells, and the heterogeneity of tumor cell populations. Based on an evolutionary computational approach, our model considers changes in mutation rate caused by lack of DNA repair processes, and the lack of apoptosis caused by mutations in p53. We find that the degree of robustness of p53 to mutations has a significant effect on the tumor heterogeneity and “fitness”, with clinical consequences for people who inherit p53 mutations.

Paper Details

Date Published: 16 February 2005
PDF: 9 pages
Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); doi: 10.1117/12.602423
Show Author Affiliations
Melissa Ryan, The Univ. of Adelaide (Australia)
Flinders Univ. (Australia)
Matthew J. Berryman, The Univ. of Adelaide (Australia)
Derek Abbott, The Univ. of Adelaide (Australia)

Published in SPIE Proceedings Vol. 5651:
Biomedical Applications of Micro- and Nanoengineering II
Dan V. Nicolau, Editor(s)

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