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Proceedings Paper

Interfacing peptides identified using phage-display screening with quantum dots for the design of nanoprobes
Author(s): Sawitri Mardyani; Anupam Singhal; Wen Jiang; Warren C. W. Chan
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Paper Abstract

The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

Paper Details

Date Published: 28 April 2005
PDF: 8 pages
Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); doi: 10.1117/12.601609
Show Author Affiliations
Sawitri Mardyani, Univ. of Toronto (Canada)
Anupam Singhal, Univ. of Toronto (Canada)
Wen Jiang, Univ. of Toronto (Canada)
Warren C. W. Chan, Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 5705:
Nanobiophotonics and Biomedical Applications II
Alexander N. Cartwright; Marek Osinski, Editor(s)

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