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Proceedings Paper

Maximum likelihood 3D reconstruction of multiple viruses from mixtures of cryo electron microscope images
Author(s): Junghoon Lee; Yili Zheng; Peter C. Doerschuk; Jinghua Tang; John E. Johnson
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Paper Abstract

A statistical model for cryo electron microscopy image formation, a maximum likelihood 3-D reconstruction algorithm, and a parallel computer implementation of the algorithm are described. The essential character of this reconstruction problem is that it concerns 2-D projections of a 3-D object where the projection orientations are unknown and the 2-D projections have SNR less than 1. A key component of a variety of algorithms is integration over projection orientation. A fast algorithm is described for performing such integrations.

Paper Details

Date Published: 11 March 2005
PDF: 8 pages
Proc. SPIE 5674, Computational Imaging III, (11 March 2005); doi: 10.1117/12.598307
Show Author Affiliations
Junghoon Lee, Purdue Univ. (United States)
Yili Zheng, Purdue Univ. (United States)
Peter C. Doerschuk, Purdue Univ. (United States)
Jinghua Tang, Scripps Research Institute (United States)
John E. Johnson, Scripps Research Institute (United States)

Published in SPIE Proceedings Vol. 5674:
Computational Imaging III
Charles A. Bouman; Eric L. Miller, Editor(s)

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