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Proceedings Paper

OCT assessment of aggregation and sedimentation in concentrated RBC suspension: comparison of experimental and Monte Carlo simulated data
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Paper Abstract

In this work, we use Monte Carlo simulation to obtain model OCT signals from a horizontally orientated blood layer at different stages of red blood cell (RBC) aggregation and sedimentation processes. The parameters for aggregating and sedimenting blood cells were chosen basing on the data available from literature and our earlier experimental studies. Two different models of simulated medium are considered: a suspension of washed RBC in physiological solution (where the aggregation does not take place) and RBC in blood plasma (which provides necessary conditions for aggregation). Good agreement of the simulation results with the available experimental data shows that the chosen optical parameters are reasonable. Dependencies of the numbers of photons contributing to the OCT signal on the number of experienced scattering events were analyzed for each simulated signal. It was shown, that maxima on these dependencies correspond to the peaks in the OCT signals related to the interfaces between the layers of blood plasma and blood cells. Their positions can be calculated from the optical thicknesses of the layers, and the absorption and scattering coefficients of the media.

Paper Details

Date Published: 29 March 2005
PDF: 8 pages
Proc. SPIE 5696, Complex Dynamics and Fluctuations in Biomedical Photonics II, (29 March 2005); doi: 10.1117/12.596850
Show Author Affiliations
Mikhail Yu. Kirillin, M.V. Lomonosov Moscow State Univ. (Russia)
Univ. of Oulu (Finland)
Alexander V Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)
Ruikang K. Wang, Cranfield Univ. at Silsoe (United Kingdom)
Risto Myllyla, Univ. of Oulu (Finland)

Published in SPIE Proceedings Vol. 5696:
Complex Dynamics and Fluctuations in Biomedical Photonics II
Valery V. Tuchin, Editor(s)

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