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Proceedings Paper

Prostate elastography: preliminary in vivo results
Author(s): S. K. Alam; E. J. Feleppa; A. Kalisz; S. Ramchandran; R. D. Ennis; Frederick L. Lizzi; C.-S. Wuu; Jeffrey A. Ketterling
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Paper Abstract

We report preliminary results from our investigation of in vivo prostate elastography. Fewer than 50% of all prostate cancers are typically visible in current clinical imaging modalities. Elastography displays a map of strain that results when tissue is externally compressed. Thus, elastography is ideal for imaging prostate cancers because they are generally stiffer than the surrounding tissue and stiffer regions usually exhibit lower strain in elastograms. In our study, digital radio-frequency (RF) ultrasound echo data were acquired from prostate-cancer patients undergoing brachytherapy. Seed placement is guided by a transrectal ultrasound (TRUS) probe, which is held in a mechanical fixture. The probe can be moved in XYZ directions and tilted. The probe face, in contact with the rectal wall, is used to apply a compression force to the immediately adjacent prostate. We also used a water-filled (acoustic) coupling balloon to compress the prostate by increasing the water volume inside the balloon. In each scan plane (transverse), we acquired RF data from successive scans at the scanner frame rate as the deformation force on the rectal wall was continuously increased. We computed strain using 1D RF cross-correlation analysis. The compression method based on fixture displacement produced low-noise elastograms that beautifully displayed the prostate architecture and emphasized stiff areas. Balloon-based compression also produced low-noise elastograms. Initial results demonstrate that elastography may be useful in the detection and evaluation of prostate cancers, occult in conventional imaging modalities.

Paper Details

Date Published: 12 April 2005
PDF: 7 pages
Proc. SPIE 5750, Medical Imaging 2005: Ultrasonic Imaging and Signal Processing, (12 April 2005); doi: 10.1117/12.596788
Show Author Affiliations
S. K. Alam, Riverside Research Institute (United States)
E. J. Feleppa, Riverside Research Institute (United States)
A. Kalisz, Riverside Research Institute (United States)
S. Ramchandran, Riverside Research Institute (United States)
R. D. Ennis, St. Luke's-Roosevelt Hospital Ctr. (United States)
Frederick L. Lizzi, Riverside Research Institute (United States)
C.-S. Wuu, New York Columbia Presbyterian Medical Ctr. (United States)
Jeffrey A. Ketterling, Riverside Research Institute (United States)

Published in SPIE Proceedings Vol. 5750:
Medical Imaging 2005: Ultrasonic Imaging and Signal Processing
William F. Walker; Stanislav Y. Emelianov, Editor(s)

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