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Proceedings Paper

Evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion using ground truth from histologic and MR data
Author(s): Celina Imielinska; Yinpeng Jin; Xin Liu M.D.; Joel Rosiene; Brad E. Zacharia; Ricardo J. Komotar M.D.; J. Mocco M.D.; Michael E. Sughrue; Bartosz Grobelny; Alex Sisti; Josh Silverberg; Joyce Khandji; Hilary Cohen; Sander Connolly Jr.; Anthony L. D'Ambrosio M.D.
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Paper Abstract

A segmentation method that quantifies cerebral infarct using rat data with ischemic stroke is evaluated using ground truth from histologic and MR data. To demonstrate alternative approach to rapid quantification of cerebral infarct volumes using histologic stained slices that requires scarifying animal life, a study with MR acquire volumetric rat data is proposed where ground truth is obtained by manual delineations by experts and automated segmentation is assessed for accuracy. A framework for evaluation of segmentation is used that provides more detailed accuracy measurements than mere cerebral infarct volume. Our preliminary experiment shows that ground truth derived from MRI data is at least as good as the one obtained from the histologic slices for evaluating segmentation algorithms for accuracy. Therefore we can develop and evaluate automated segmentation methods for rapid quantification of stroke without the necessitating animal sacrifice.

Paper Details

Date Published: 29 April 2005
PDF: 10 pages
Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); doi: 10.1117/12.596662
Show Author Affiliations
Celina Imielinska, Columbia Univ. (United States)
Yinpeng Jin, Columbia Univ. (United States)
Xin Liu M.D., Columbia Univ. (United States)
Joel Rosiene, Eastern Connecticut State Univ. (United States)
Brad E. Zacharia, Columbia Univ. (United States)
Ricardo J. Komotar M.D., Columbia Univ. (United States)
J. Mocco M.D., Columbia Univ. (United States)
Michael E. Sughrue, Columbia Univ. (United States)
Bartosz Grobelny, Columbia Univ. (United States)
Alex Sisti, Columbia Univ. (United States)
Josh Silverberg, Columbia Univ. (United States)
Joyce Khandji, Columbia Univ. (United States)
Hilary Cohen, Columbia Univ. (United States)
Sander Connolly Jr., Columbia Univ. (United States)
Anthony L. D'Ambrosio M.D., Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 5747:
Medical Imaging 2005: Image Processing
J. Michael Fitzpatrick; Joseph M. Reinhardt, Editor(s)

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