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Proceedings Paper

A computerized approach for estimating pulmonary nodule growth rates in three-dimensional thoracic CT images based on CT density histogram
Author(s): Yoshiki Kawata; Noboru Niki; Hironobu Ohmatsu; Masahiko Kusumoto; Ryutaro Kakinuma D.D.S.; Kiyoshi Mori; Kozo Yamada; Hiroyuki Nishiyama; Kenji Eguchi M.D.; Masahiro Kaneko; Noriyuki Moriyama
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Paper Abstract

In research and development of computer-aided differential diagnosis, there is now a widespread interest in the use of nodule doubling time for measuring the volumetric changes of pulmonary nodule. To assess nodule status requires not only the measurement of volume changes but also one of nodule density variations. This paper proposes a computerized approach to measure nodule density variation inside small pulmonary nodule using CT images. The approach consists of five steps: (1) nodule segmentation, (2) computation of CT density histogram, (3) nodule classification based on CT density histogram and size, (4) computation of doubling time based on CT density histogram, and (5) classification between benign and malignant. Our approach was applied to follow-up scans of lung nodules. The preliminary experimental result demonstrated that our approach has a highly potential usefulness to assess the nodule evolution using high-resolution CT images.

Paper Details

Date Published: 29 April 2005
PDF: 11 pages
Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); doi: 10.1117/12.595099
Show Author Affiliations
Yoshiki Kawata, Univ. of Tokushima (Japan)
Noboru Niki, Univ. of Tokushima (Japan)
Hironobu Ohmatsu, National Cancer Ctr. Hospital East (Japan)
Masahiko Kusumoto, National Cancer Ctr. Hospital (Japan)
Ryutaro Kakinuma D.D.S., National Cancer Ctr. Research Ctr. for Cancer Prevention and Screening (Japan)
Kiyoshi Mori, Tochigi Cancer Ctr. (Japan)
Kozo Yamada, Kanaga Cancer Ctr. (Japan)
Hiroyuki Nishiyama, The Social Health Insurance Medical Ctr. (Japan)
Kenji Eguchi M.D., Tokai Univ. (Japan)
Masahiro Kaneko, National Cancer Ctr. Hospital (Japan)
Noriyuki Moriyama, National Cancer Ctr. Research Ctr. for Cancer Prevention and Screening (Japan)

Published in SPIE Proceedings Vol. 5747:
Medical Imaging 2005: Image Processing
J. Michael Fitzpatrick; Joseph M. Reinhardt, Editor(s)

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