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Proceedings Paper

X-ray dark-field imaging and potential of its clinical application
Author(s): Daisuke Shimao; Hiroshi Sugiyama; Toshiyuki Kunisada M.D.; Anton Maksimenko; Fukai Toyofuku; Ei Ueno M.D.; Katsuhito Yamasaki; Chiho Obayashi; Kazuyuki Hyodo; Gang Li; Lin Pan; Xiaoming Jiang; Masami Ando
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Paper Abstract

X-ray dark-field imaging (DFI) due to refraction is under development with intension of its clinical application. In this system we have adopted an asymmetric-cut monochro-collimator (M) and an angular analyzer (A) of Si 440 diffraction at 35 keV of X-rays. By choosing an appropriate thickness T of A that satisfies the condition T = ΛN where Λ is the extinction distance and N integer the transmissivity in the region of |W| (angular parameter) < 1 should be theoretically almost zero and |W| > 1 should be approximately 70-80%. This has been experimentally proven. Under this condition the X-rays whose propagation direction may not change such as those receiving only absorption will not go into the forward diffraction direction after A but go into the diffraction direction, while the X-rays refracted by object may go into the forward diffraction direction after A. We have settled two targets of clinical views: soft tissues at joints and early check of breast cancer. A first clear image of articular cartilage of small joint was successfully obtained using a proximal interphalangeal joint that was amputated from a cadaver. Since larger view field is needed for clinical use the size of approximately 90 mm in square has been successfully achieved. Using this beam articular cartilage of knee and shoulder joints from the same cadaver have been successfully visualized. Further visibility test by the DFI is under way for a phantom of breast cancer, paraffin fixed sliced breast samples containing micro-calcification, tumor and excised breast tissue.

Paper Details

Date Published: 20 April 2005
PDF: 8 pages
Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); doi: 10.1117/12.595021
Show Author Affiliations
Daisuke Shimao, Graduate Univ. for Advanced Studies (Japan)
Hiroshi Sugiyama, Graduate Univ. for Advanced Studies (Japan)
Photon Factory, KEK (Japan)
Toshiyuki Kunisada M.D., Okayama Univ. (Japan)
Anton Maksimenko, Photon Factory, KEK (Japan)
Fukai Toyofuku, Kyushu Univ. (Japan)
Ei Ueno M.D., Univ. of Tsukuba (Japan)
Katsuhito Yamasaki, Spring-8, JASRI (Japan)
Kobe Univ. (Japan)
Chiho Obayashi, Kobe Univ. (Japan)
Kazuyuki Hyodo, Photon Factory, KEK (Japan)
Gang Li, Beijing Synchrotron Radiation Facility, IHEP (China)
Lin Pan, China-Japan Friendship Hospital (China)
Xiaoming Jiang, Beijing Synchrotron Radiation Facility, IHEP (China)
Masami Ando, Graduate Univ. for Advanced Studies (Japan)
Photon Factory, KEK (Japan)

Published in SPIE Proceedings Vol. 5745:
Medical Imaging 2005: Physics of Medical Imaging
Michael J. Flynn, Editor(s)

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