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Proceedings Paper

Photodynamic diagnosis of early stage malignancies: preliminary results in urology and pneumonology
Author(s): Reinhold Baumgartner; M. Kriegmair; Dieter Jocham; Alfons G. Hofstetter; Rainer Huber; O. Karg; Karl Haeussinger
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Paper Abstract

on the basis of clinical protocols, phase Il-studies have been started to evaluate photodynamic diagnosis (PDD) for early visualization of cancer in bladder and lung. As tumor marker the fluorescent and photosensitizing polyporphyrin Photofrin II is used in a dose, which has been proven to avoid photosensitization of the patients skin. The drug is administered systemically in a concentration of mostly 0,4 mg/kg bodyweight. Fluorescence of Photofrin II in tissue is detected by an image intensifying CCD-camera coupled to endoscopes usually used in both medical disciplines. Video presentation of the marker fluorescence occurs with high contrast due to realtime image processing following two wavelength excitation of the tissue with laser light. Keypoint of the new diagnostic method is the correlation of the fluorescence contrast and the histological examination of biopsies removed from these areas. As example 87 biopsies has been taken from 1 7 patients suffering from bladder cancer. While all tumorous samples (n = 1 6) show strong fluorescence, about 30% of the biopsies are judged as false positive. A variety of premalignant diseases has been found in these sections. No false negative results are obtained up to now.

Paper Details

Date Published: 6 May 1992
PDF: 6 pages
Proc. SPIE 1641, Physiological Monitoring and Early Detection Diagnostic Methods, (6 May 1992); doi: 10.1117/12.59354
Show Author Affiliations
Reinhold Baumgartner, GSF-Zentrales Laserlab. and Univ. Muenchen (Germany)
M. Kriegmair, Univ. Muenchen (Germany)
Dieter Jocham, Univ. Luebeck (Germany)
Alfons G. Hofstetter, Univ. Muenchen (Germany)
Rainer Huber, Medizinische Klinik Innenstadt (Germany)
O. Karg, Zentralkrankenhaus Gauting (Germany)
Karl Haeussinger, Zentralkrankenhaus Gauting (Germany)

Published in SPIE Proceedings Vol. 1641:
Physiological Monitoring and Early Detection Diagnostic Methods
Thomas S. Mang, Editor(s)

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