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Proceedings Paper

Discrimination of atherosclerotic plaque constituents based on local measurements of optical attenuation coefficients by OCT
Author(s): Freek J. van der Meer; Jop Perree; Dirk J. Faber; David M. Baraznji Bassoon; Maurice C. G. Aalders; Ton G. van Leeuwen
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Paper Abstract

Imaging of human autopsy samples was performed from the luminal side with a high (3.5 μm axial and 7 μm lateral) resolution OCT system (around 800 nm) or a regular (15-20 μm axial and 20 μm lateral resolution) OCT system (around 1300 nm). For each sample, dimensions were measured by histomorphometry and OCT and the optical attenuation was measured. Quantitative analysis showed a strong and significant correlation between OCT and histology cap thickness measurements for both OCT systems. For both systems, the measured attenuation coefficients of diffuse intimal thickening and lipid-rich regions differed significantly from media and calcifications. Both the high and regular resolution OCT systems can precisely image the atherosclerotic plaques. Quantitative analysis of the OCT signals allowed in situ determination of the intrinsic optical attenuation coefficient of atherosclerotic tissue components within regions of interest, which can further help to discriminate the plaque and arterial wall components.

Paper Details

Date Published: 13 April 2005
PDF: 7 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.592711
Show Author Affiliations
Freek J. van der Meer, Academic Medical Ctr. Amsterdam (Netherlands)
Jop Perree, Academic Medical Ctr. Amsterdam (Netherlands)
Dirk J. Faber, Academic Medical Ctr. Amsterdam (Netherlands)
David M. Baraznji Bassoon, Academic Medical Ctr. Amsterdam (Netherlands)
Maurice C. G. Aalders, Academic Medical Ctr. Amsterdam (Netherlands)
Ton G. van Leeuwen, Academic Medical Ctr. Amsterdam (Netherlands)
Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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