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Proceedings Paper

Direct detection of the interaction of tiny analytes with receptors using an advanced plasmonic biosensor
Author(s): Fan-Ching Chien; K.-T. Huang; C.-Y. Lin; Shean-Jen Chen
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Paper Abstract

The interaction between tiny-molecular-weight analytes and receptors can be detected directly using advanced plasmonic biosensors. This paper proposes a plasmonic biosensor with Au nanoclusters embedded in a dielectric film. The sensor uses the attenuated total reflection (ATR) method to excite both the surface plasmons (SPs) and the particle plasmons (PPs). The local electro-magnetic (EM) field is enhanced by controlling the size and volume fraction of the embedded Au nanoparticles. The developed biosensor demonstrates a 10-fold improvement in resolution compared to a conventional surface plasmon resonance (SPR) biosensor. Using the proposed ultra-sensitive plasmonic biosensor, a direct detection approach is adopted to analyze the interactions of tiny molecules (< 200 Da) without the need for high molecular weight competitors or explicit labeling. The plasmonic biosensor developed in this paper provides a rapid diagnostic capability and has considerable potential for use in pharmaceutical research.

Paper Details

Date Published: 31 March 2005
PDF: 11 pages
Proc. SPIE 5703, Plasmonics in Biology and Medicine II, (31 March 2005); doi: 10.1117/12.592530
Show Author Affiliations
Fan-Ching Chien, National Central Univ. (Taiwan)
K.-T. Huang, National Central Univ. (Taiwan)
C.-Y. Lin, National Cheng Kung Univ. (Taiwan)
Shean-Jen Chen, National Cheng Kung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5703:
Plasmonics in Biology and Medicine II
Tuan Vo-Dinh; Joseph R. Lakowicz; Zygmunt K. Gryczynski, Editor(s)

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