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Proceedings Paper

Polarization-sensitive optical coherence tomography for monitoring wound healing process
Author(s): Sang-Won Lee; Jung-Taek Oh; Youn-Soo Kim; Beop-Min Kim
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Paper Abstract

We use polarization sensitive optical coherence tomography (PS-OCT) to monitor wound healing processes in-vitro and in-vivo, which are affected by various drugs. Five rabbit subjects are used for the in-vitro studies and another five are used for in-vivo studies. The in-vitro studies are conducted to compare the PS-OCT images with histopathology. For each subject, three biopsy lesions are created on each ear: one site is not treated (control), the second site is treated with sphingosyl phosphoryl choline (SPC), which is known to promote healing, and the last is administered with tetra acetyl phytosphingo sine (TAPS), which negatively affects the healing process. Each site is examined with a PS-OCT system and conventional histopathology at 1-, 4-, 7-, 10-, and 14-days after wound generation. The phase retardation values are quantified for all cases and our results suggest that PS-OCT may be a useful tool for visualization of collagen fiber regeneration during the healing process; therefore, various drug effects can be noninvasively monitored.

Paper Details

Date Published: 13 April 2005
PDF: 5 pages
Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); doi: 10.1117/12.592511
Show Author Affiliations
Sang-Won Lee, Yonsei Univ. (South Korea)
Jung-Taek Oh, Institute for Medical Engineeering (South Korea)
Youn-Soo Kim, Chungbuk National Univ. (South Korea)
Beop-Min Kim, Yonsei Univ. (South Korea)

Published in SPIE Proceedings Vol. 5690:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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