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Proceedings Paper

Development of an intravascular laser treatment with an infrared free electron laser
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Paper Abstract

A cholesterol ester is selective dissociated by MIR-FEL irradiation with wavelength of 5.75 μm correspond to C=O stretching vibration of ester bond. To evaluate the optimum irradiation condition for cholesterol ester decomposition without normal endothelium cell damage, we perform a 5.75 μm-FEL irradiation to a two-layer vessel model which is cholesterol oleate as a model of atherosclerotic lesions and gelatin as a model of endothelial cells. The ester decomposition and gelatin damege depends on total power density of 5.75 μm-FEL provided the two-layer model. Exposure of the FEL with power density exceed 17.8 W/cm2 decomposed cholesterol ester thorough gelain layer of 15 μm thickness. If FEL with power density of 25.0 W/cm2 is exposed during 10 seconds, the gelatin is evaporized. Therefore, the optimum condition for ester decomposition without gelatin evaporation is between 75 J/cm2 from 20 J/cm2 in the case of 15 μm gelatin layer thickness. The maximum ester decomposition rate without gelatin vaporization is 71% on FEL of power density of 17.8 W/cm2 for 10 seconds.

Paper Details

Date Published: 15 April 2005
PDF: 7 pages
Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); doi: 10.1117/12.591912
Show Author Affiliations
Sachiko Suzuki-Yoshihashi, Osaka Univ. (Japan)
Katsunori Ishii, Osaka Univ. (Japan)
Nara Institute of Science and Technology (Japan)
Tomoko Sano, Osaka Univ. (China)
Kunio Awazu, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 5695:
Optical Interactions with Tissue and Cells XVI
Steven L. Jacques; William P. Roach, Editor(s)

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